Welcome to the Bornscheuer group!

Our major research target is the development of tailor-made biocatalysts suitable for industrial applications.
Please enjoy to explore our web-site to get a more detailed description of the group, its projects, publications and other information.

Overview of research activities:

Access to biocatalysts

• Identification of new biocatalysts by screening, e.g. from strain collections
• In silico discovery of novel enzymes
• Cloning and functional expression in suitable microbial hosts
• Creation of tailor-made enzymes using directed (molecular) evolution and rational protein design
• Commercial enzymes

Methods

• Development of High-Throughput-Systems for directed evolution
• Development & application of bioinformatic tools
• Cloning, expression, purification, characterization of enzymes
• Chemical syntheses
• Chiral analysis (e.g. via gas chromatography or HPLC)
• Process development (e.g. continuous enzymatic synthesis)

 

Enzymes studied

• Transaminases
• Baeyer-Villiger Monooxygenases
• Esterases
• Lipases
• Oxidases
• Others

Applications

• Synthesis of optically pure compounds, e.g. for pharmaceutical applications
• Modification of fats and oils, e.g. structured triglycerides
• Synthesis of detergents, e.g. sugar esters

 

News

We organize two conferences in 2012 at our Institute:

Aug. 29-31st 2012:
Protein Engineering for Biocatalysis

Sept. 19-21st 2012:
Biocatalysis in Lipid Modification

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Our publication made the cover of Nature Chem. Biol, Nov. 2010:

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Author profile:

An author profile about Uwe Bornscheuer has been published in Angew. Chem. Int. Ed.

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Flyer available:

English version (pdf)

German version (pdf)

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Cluster Partner:

Partner in the 'White Biotechnology' cluster 'Biokatalyse2021' funded by the BMBF.

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Contact
Prof. Dr. Uwe Bornscheuer
Institute of Biochemistry
Dept. of Biotechnology & Enzyme Catalysis
Felix-Hausdorff-Str. 4
D-17487 Greifswald/ Germany

Phone:
+49 (0)3834-86-4367
+49 (0)3834-86-4391 (Secr.)
Fax:
+49 (0)3834-86-794367
E-Mail:
uwe.bornscheuer

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